• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal Dylight 633

Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal Dylight 633
374,35 €
Artikelnummer: STRSPC-952D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal Dylight 633

Details

The CDC-like kinase 1 (CLK1) dually phosphorylates serine- and arginine-rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/thre-onine residues. CLK1 activity is negatively regulated by steric constraints mediated by the N-terminal domain and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain.

A 1:250 dilution of SPC-952 was sufficient for detection of CLK1 (pSer337 + pThr338) in 10 µg of 293T cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Zusatzinformation

Artikelnummer STRSPC-952D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SPC-952D-DY633
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download