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ErbB2 Antibody (pTyr1248): APC/Cy7, Polyclonal

ErbB2 Antibody (pTyr1248): APC/Cy7, Polyclonal
440,15 €
Artikelnummer: STRSPC-967D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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ErbB2 Antibody (pTyr1248): APC/Cy7, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human ErbB2 (pTyr1248) Polyclonal
Target: ErbB2 (pTyr1248)
Purification: Peptide Affinity Purified
Specificity: Detects 137.91 kDa.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus, Cell Membrane
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr1248 of human ErbB2 (AA1245-1251)
Scientific Background: ErbB2 is a receptor-tyrosine kinase of the epidermal growth factor receptor family,that is activated upon binding NRG with ErbB3. NRG acts as an autocrine factor produced in ovarian carcinomas. ERBB2 needs a coreceptor for ligand binding. Activates MAPK and PI3K pathways and is involved in cell proliferation, prolonging and enhancing survival signals, differentiation and apoptosis. Amplification and overexpression of ERBB2 is associated with numerous cancers. The increase of ERBB2 protein in breast tumour can be up to 100-fold.

Zusatzinformation

Artikelnummer STRSPC-967D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SPC-967D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download