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ERK1 Antibody (pTyr204): Dylight 350, Polyclonal

ERK1 Antibody (pTyr204): Dylight 350, Polyclonal
444,39 €
Artikelnummer: STRSPC-974D-DY350

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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ERK1 Antibody (pTyr204): Dylight 350, Polyclonal, Host: Rabbit


Rabbit Anti-Human ERK1 (pTyr204) Polyclonal
Target: ERK1 (pTyr204)
Purification: Peptide Affinity Purified
Specificity: Detects 43.136 kDa.
Conjugate: Dylight 350
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr204 of human ERK1 (AA 204-209)
Scientific Background: ERK1 or MAPK3 is ubiquitously expressed protein serine/threonine kinase involved in regulating cellular differentiation and proliferation in response to extracellular mitogens or growth factors. MAPK3 is activated by upstream signalling by monomeric G-proteins. MAPK3 activation leads to its translocation from the cytosol to the nucleus where it can target substrate proteins involved in cell cycle regulation; Cyclin D1, suppression of apoptosis; BCL2 and BAD, tumour supression; p53, cell migration; PAI-1, and MHCII mediated immune response; PPARg1. Dysfunction of MAPK3 expression and activity has been observed in a variety of cancers. Predominantly overexpression of MAPK3 or constitutive activation has been observed in cancer cell lines. Activation of MAPK3 does not appear to be due to mutations in the protein itself but rather aberrant signalling in upstream factors including Raf, Ras and epidermal growth factor receptor. MAPK3 may also have a role in promoting metastasis in invasive tumours.


Artikelnummer STRSPC-974D-DY350
Hersteller Stressmarq Biosciences
Herstellernummer SPC-974D-DY350
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download