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ERK2 Antibody (pThr185 + pTyr187): Dylight 633, Polyclonal

ERK2 Antibody (pThr185 + pTyr187): Dylight 633, Polyclonal
391,36 €
Artikelnummer: STRSPC-975D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
ERK2 Antibody (pThr185 + pTyr187): Dylight 633, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human ERK2 (pThr185 + pTyr187) Polyclonal
Target: ERK2 (pThr185 + pTyr187)
Purification: Peptide Affinity Purified
Specificity: Detects 41.39 kDa.
Conjugate: Dylight 633
Immunogen Species: Human
Cellular Location: Cytoplasm, Cytoskeleton, Spindle, Nucleus
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr185 and Tyr187 of human ERK2 (AA 182-188)
Scientific Background: ERK2 or MAPK1 is a protein-serine/threonine kinase. Phosphorylates many diffrent transcription factors, such as ELK1. Acts as transcriptional repressor by binding directly to DNA. Essential for cyclin D1 induction. MAPK1 phosphoryltaes BCL2, which contributes to cell survival, the suppression of the apoptotic effect of BAD and up-regulation of the antiapoptotic protein MCL-1. Regulates accumulation of p53 during DNA damage response. Constitutively active in many human tumours, supposedly due to altered RAS, RAF, EGFR or other upstream elements. ERK/MAPK pathway was shown to promote cell motilty and tumour cell migration.

Zusatzinformation

Artikelnummer STRSPC-975D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SPC-975D-DY633
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download