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FAK Antibody (pTyr577): Dylight 594, Polyclonal

FAK Antibody (pTyr577): Dylight 594, Polyclonal
401,97 €
Artikelnummer: STRSPC-978D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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FAK Antibody (pTyr577): Dylight 594, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human FAK (pTyr577) Polyclonal
Target: FAK (pTyr577)
Purification: Peptide Affinity Purified
Specificity: Detects 119.233 kDa.
Tissue Specificity: Highly expressed in brain but found in heart, placenta, lung, kidney and skeletal muscle.
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Cell Junctions, Focal Adhesion, Cell Membrane
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr577 of human FAK (AA574-580)
Scientific Background: FAK, also known as PTK2, is a non-receptor protein-tyrosine kinase that is activated by tyrosine-phosphorylation in response to integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands. It serves as adaptor protein. It is linked to the MAPK pathway via Grb2, and is also linked to PI3K and PLC gamma pathways. It plays a role as a scaffold for MDM2-mediated p53 degradation, and has been implicated in regulation of cell-cell contacts, microtubule stability and control of gene transcription. FAK has high expression levels in various human cancers as it promotes tumour cell motility, matrix degradation, angiogenesis and suppresses apoptosis, anoikis and senescence.

Zusatzinformation

Artikelnummer STRSPC-978D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SPC-978D-DY594
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download