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FGFR2 Antibody (pTyr656 + pTyr657): APC/Cy7, Polyclonal

FGFR2 Antibody (pTyr656 + pTyr657): APC/Cy7, Polyclonal
440,15 €
Artikelnummer: STRSPC-982D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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FGFR2 Antibody (pTyr656 + pTyr657): APC/Cy7, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal
Target: FGFR2 (pTyr656 + pTyr657)
Purification: Peptide Affinity Purified
Specificity: Detects 92.025 kDa.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cell Membrane, Golgi Apparatus, Cytoplasmic Vesicle
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr656 and Tyr657 of human FGFR2 (AA653-659)
Scientific Background: FGFR2 plays an important role in regulation of cell differentiation, proliferation, migration and apoptosis. It is involved in differentiation and proliferation of osteoblasts and keratinocytes; activates several signalling cascades, such as the MAPK and AKT1 pathway. Missense mutations are associated with ligand independent activation of TK25 (FGFR2) or an activating autocrine signalling loop. Mutations and gene amplifications are involved in various human cancers, and overexpression has been associated with tumourigenesis. Certain missense mutations have been associated with breast, ovarian, endometrial, prostate, bladder, gastric and lung cancers.

Zusatzinformation

Artikelnummer STRSPC-982D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SPC-982D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download