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FGFR3 Antibody (pTyr647 + pTyr648): APC/Cy7, Polyclonal

FGFR3 Antibody (pTyr647 + pTyr648): APC/Cy7, Polyclonal
440,15 €
Artikelnummer: STRSPC-983D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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FGFR3 Antibody (pTyr647 + pTyr648): APC/Cy7, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human FGFR3 (pTyr647 + pTyr648) Polyclonal
Target: FGFR3 (pTyr647 + pTyr648)
Purification: Peptide Affinity Purified
Specificity: Detects 87.710 (110-120) kDa.
Tissue Specificity: Expressed in brain, kidney and testis
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cell Membrane, Cytoplasmic Vesicle, Endoplasmic Reticulum
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr647 and Tyr648 of human FGFR3 (AA644-651)
Scientific Background: FGFR3 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). Extracellular ligand binding induces homo- or hetero- dimerization of FGFR to activate signalling. FGFRs have an essential role in regulating cellular differentiation, proliferation and apoptosis. The FGFR3 isoform is specifically involved in chondrocyte development which is physiologically linked to normal skeleton development. Defects in FGFR3 can lead to dwarfism. Overexpressed FGFR3 can promote activation of SHP2 and STAT signalling pathways.Mutations which promote constitutive dimerization of FGFR and kinase activation or impairs internalization and degradation of the receptor have been observed in bladder, skin and oral cancers.

Zusatzinformation

Artikelnummer STRSPC-983D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SPC-983D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download