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FNIP1 Antibody: Dylight 594, Polyclonal

FNIP1 Antibody: Dylight 594, Polyclonal
357,42 €
Artikelnummer: STRSPC-718D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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FNIP1 Antibody: Dylight 594, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human FNIP1 Polyclonal
Target: FNIP1
Purification: Peptide Affinity Purified
Specificity: Detects ~130 kDa.
Tissue Specificity: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Cytoplasm
Immunogen: Synthetic peptide from the mid-protein of Human FNIP1
Scientific Background: Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).
Reference: 1. Woodford, M. R. et al. (2016) Nature Com. 12037.2. Baba, M. et al. (2006) Proc Natl Acad Sci U.S.A. 103(42):15552-7.3. www.uniprot.org/uniprot/Q8TF46

Zusatzinformation

Artikelnummer STRSPC-718D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SPC-718D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download