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PERK Antibody (pThr892): Dylight 405, Polyclonal

PERK Antibody (pThr892): Dylight 405, Polyclonal
418,94 €
Artikelnummer: STRSPC-963D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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PERK Antibody (pThr892): Dylight 405, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human PERK (pThr892) Polyclonal
Target: PERK (pThr892)
Purification: Peptide Affinity Purified
Specificity: Detects 125.147 kDa.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Endoplasmic Reticulum Membrane
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr892 of human PERK (AA889-895)
Scientific Background: PERK (eukaryotic translation initiation factor 2-α kinase 3, eIF2α kinase 3, PEK, WRS) is a Ser/Thr protein kinase, type I membrane protein of the endoplasmic reticulum that is abundant in secretory tissues and is inducible by ER-stress. PERK phosphorylates the α subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, a reduction of translation initiation and repression of global protein synthesis. PERK may serve as an effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. PERK dimerizes with HSPA5/BIP in resting cells and oligomerizes in ER-stressed cells. Perturbation in protein folding in the endoplasmic reticulum (ER) can promote dissociation from HSPA5/BIP and oligomerization, resulting in autophosphorylation and kinase activity induction.

Zusatzinformation

Artikelnummer STRSPC-963D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SPC-963D-DY405
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download