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ROR2 Antibody: Dylight 488, Polyclonal

ROR2 Antibody: Dylight 488, Polyclonal
354,24 €
Artikelnummer: STRSPC-739D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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ROR2 Antibody: Dylight 488, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human ROR2 Polyclonal
Target: ROR2
Purification: Peptide Affinity Purified
Specificity: Detects 104.7 kDa. Bands at ~60, 35 kDa are possible degradation products.
Tissue Specificity:
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cell Membrane, Single-Pass Type I Membrane Protein
Immunogen: Synthetic peptide of Human ROR2 (100-200 aa), conjugated to Keyhole Limpet Haemocyanin (KLH).
Scientific Background: ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.

Zusatzinformation

Artikelnummer STRSPC-739D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SPC-739D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Rat (Rattus)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Immunohistochemistry, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download