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SMAD3 Antibody: Dylight 405, Polyclonal

SMAD3 Antibody: Dylight 405, Polyclonal
364,85 €
Artikelnummer: STRSPC-729D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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SMAD3 Antibody: Dylight 405, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human SMAD3 Polyclonal
Target: SMAD3
Purification: Peptide Affinity Purified
Specificity: Detects 48 kDa, additional bands due to post translational modifications.
Tissue Specificity:
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus
Immunogen: Synthetic peptide of Human SMAD3 (110-210aa), conjugated to Keyhole Limpet Haemocyanin (KLH).
Scientific Background: Members of the Smad family of cell signaling molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. There are three distinct classes of Smads: the receptor-regulated Smads (R-Smads), the common-mediator Smad (co-Smad), and the antagonistic or inhibitory Smads. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression.
Reference: 1. Heldin C.H. et al. (1997) Nature. 390: 465-471.2. Attisano L. and Wrana, J.L. (1998) Curr Opin Cell Biol. 10: 188-194.3. Massagué J. (1998) Annu Rev Biochem. 67: 753-791.4. Whitman M. (1998) Genes Dev. 12: 2445-2462.5. Wu G. et al. (2000) Science. 287: 92-97.6. Abdollah S., et al. (1997) J. Biol. Chem. 272: 27678-27685.7. Souchelnytskyi S., et al. (1997) J. Biol. Chem. 272: 28107-28115.8. Liu X., et al. (1997) Proc. Natl. Acad. Sci. USA. 94: 10669-10674.

Zusatzinformation

Artikelnummer STRSPC-729D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SPC-729D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Immunohistochemistry, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download