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Tau Antibody: Dylight 594, Polyclonal

Tau Antibody: Dylight 594, Polyclonal
356,36 €
Artikelnummer: STRSPC-801D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Tau Antibody: Dylight 594, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Tau Polyclonal
Target: Tau
Purification: Protein A Purified
Specificity: Detects ~45.8kda.
Tissue Specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Cytoskeleton, Plasma Membrane, Cell Membrane, Peripheral Membrane Protein, Cytoplasmic Side, Cytosol, Axon, Microtubule, Microtubule Associated Complex, Tubulin Complex, Nucleus, Nuclear Periphery, Nuclear Speck, Axolemma Plasma Membrane, Axolemma, Cytoplasm, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Dendrite, Growth Cone, Neurofibrillary Tangle, Neuronal Cell Body
Immunogen: Synthetic peptide from the full length of Human Tau
Scientific Background: Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
Reference: 1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.5. Guo, J. and Lee, M.Y. (2013). FEBS Lett. 587(6): 717-723.6. Alberici, A. et al. (2004). J Neurol Neurosurg Psychiatry. 75:1607-1610.

Zusatzinformation

Artikelnummer STRSPC-801D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SPC-801D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode ELISA, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download