• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

AHA1 Antibody: Dylight 594, Monoclonal

AHA1 Antibody: Dylight 594, Monoclonal
371,21 €
Artikelnummer: STRSMC-173D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
AHA1 Antibody: Dylight 594, Monoclonal, Clone: 25F2.D10, Host: Rat, Isotype: IgG2a

Details

Rat Anti-Mouse AHA1 Monoclonal IgG2a Kappa
Target: AHA1
Purification: Protein G Purified
Specificity: Detects ~38kDa. Can run up to 45kDa on SDS Page.
Conjugate: Dylight 594
Immunogen Species: Mouse
Cellular Location: Cytoplasm, Endoplasmic Reticulum
Immunogen: Mouse Aha1
Scientific Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Reference: 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

Zusatzinformation

Artikelnummer STRSMC-173D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-173D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Rat
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download