VPS35 Antibody, Clone 7E4: RPE

Mouse Anti-Human VPS35 Monoclonal IgG2a
Artikelnummer
STRSMC-602D-RPE
Verpackungseinheit
100 µg
Hersteller
Stressmarq Biosciences

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Target: VPS35.

Conjugate: RPE.

Product Type: Monoclonal.

Clone Number: 7E4.

Immunogen: Full length recombinant human VSP35.

Swiss-Prot: Q96QK1.

Purification: Protein G Purified.

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide.

Concentration: 1 mg/ml.

Specificity: Detects ~92 kDa.

Cellular Localization: Endosome, Lysosome, Vesicles, Cytoplasm, Membrane.

Tissue Specificity: Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.

Scientific Background: Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).

References: 1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–1672. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–1753. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Mehr Informationen
Artikelnummer STRSMC-602D-RPE
Hersteller Stressmarq Biosciences
Hersteller Artikelnummer SMC-602D-RPE
Verpackungseinheit 100 µg
Mengeneinheit STK
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Methode Immunofluorescence, Immunoprecipitation, Western Blotting, Immunocytochemistry
Isotyp IgG2a
Human Gene ID 55737
Wirt Mouse
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