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Active Human Recombinant A53T Mutant Alpha Synuclein Protein Preformed Fibrils

Active Human Recombinant A53T Mutant Alpha Synuclein Protein Preformed Fibrils
551,88 €
Artikelnummer: STRSPR-326C

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Active Human Recombinant A53T Mutant Alpha Synuclein Protein Preformed Fibrils (Type 1)

Details

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). The A53T mutation is a missense point mutation where alanine is replaced by threonine at the 53rd amino acid. This mutation has been linked to early-onset Parkinson's Disease (7) and increased rates of alpha synuclein fibrillization (8).

Certified >95% pure using SDS-PAGE analysis.

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Zusatzinformation

Artikelnummer STRSPR-326C
Hersteller Stressmarq Biosciences
Herstellernummer SPR-326C
Verpackungseinheit 2x100 µg
Mengeneinheit PAK
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Keine Herstellerangabe
Methode In Vitro Assay, In Vivo Assay, Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE), Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Auf Anfrage
MSDS Download