C-C motif chemokine 2 (CCL2) is a 76 amino acid Cys-Cys chemokine that has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It is also known as monocyte chemoattractant protein 1 (MCP1), monocyte chemotactic and activating factor (MCAF), and small inducible cytokine A2. CCL2 is a ligand for the G protein coupled receptors CCR2 and CCR4, and induces chemotactic migration of monocytes, activated T cells, basophils, NK cells and dendritic cells, but not neutrophils or eosinophils. CCL2 can augment monocyte anti-tumor activity and may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC chemokines are chemotactic cytokines characterized by two adjacent cysteines that induce directed chemotaxis in nearby responsive cells.
|Wirt / Host||Keine Herstellerangabe|
|Gene ID|| NCBI (externer Link)|
|Datenblatt|| Auf Anfrage|