• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Human Prorenin, C-terminal 8x His tag

Human Prorenin, C-terminal 8x His tag
1.991,30 €
Artikelnummer: MOIHPREN-HIS-1

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Human Prorenin, C-terminal 8x His tag, 1,0 mg

Details

Recombinantly produced in HEK cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2).

Zusatzinformation

Artikelnummer MOIHPREN-HIS-1
Hersteller Molecular Innovations
Herstellernummer HPREN-HIS-1
Verpackungseinheit 1,0 mg
Mengeneinheit FL
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Keine Herstellerangabe
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Auf Anfrage
MSDS Download