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Human Prorenin, Native

Human Prorenin, Native
263,55 €
Artikelnummer: MOIHPREN-0,1

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Human Prorenin, Native, 0,1 mg

Details

Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2).

Zusatzinformation

Artikelnummer MOIHPREN-0,1
Hersteller Molecular Innovations
Herstellernummer HPREN-0,1
Verpackungseinheit 0,1 mg
Mengeneinheit FL
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Keine Herstellerangabe
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Auf Anfrage
MSDS Download