X-C motif chemokine 1 (XCL1) is a 93 amino acid XC chemokine that is chemotactic for lymphocytes but not for monocytes or neutrophils. It is also known as lymphotactin or single c motif 1 (SCM-1) and is closely related to its paralog XCL2 or SCM-1-beta. XCL1 interconverts between monomeric and dimeric forms under physiological conditions. XCL1 monomer is a ligand for the G protein coupled receptor XCR1 while the XCL1 dimer has decreased binding affinity. XCL1 is expressed at high levels in the spleen, moderate levels in peripheral leukocytes and at low levels in the lung, colon and small intestine. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The XC chemokines are a two member subfamily of chemotactic cytokines that induce directed chemotaxis in nearby responsive cells and retain only two of the four cysteines characteristically conserved in chemokines.
|Wirt / Host||Keine Herstellerangabe|
|Gene ID|| NCBI (externer Link)|
|Datenblatt|| Auf Anfrage|