Interleukin-2 (IL-2) is a O-glycosylated four alpha-helix bundle cytokine that is produced by T-cells in response to antigenic or mitogenic stimulation. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells and is required for T-cell proliferation and other activities crucial to regulation of the immune response. Mouse IL-2 (Ala21-Gln169) is expressed recombinantly, purified by chromatography, sterile filtered and lyophilized. >95percent pure by SDS-PAGE and biologically active as measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T-cells. (Gearing and Bird (1987) Production and assay of interleukin 2. In Lymphokines and Interferons: A Practical Approach (Clemens et al. eds.) pp. 291-301). The ED50 for this effect is typically < 1.0 ng/ml. Add deionized water to original volume, aliquot and freeze unused portion.
|Wirt / Host||Keine Herstellerangabe|
|Gene ID|| NCBI (externer Link)|
|Datenblatt|| Auf Anfrage|