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Mouse Thrombopoietin, chiMAX Fc Fusion Protein

Mouse Thrombopoietin, chiMAX Fc Fusion Protein
329,10 €
Artikelnummer: MOIMTPO-FC-0,1

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Mouse Thrombopoietin, chiMAX Fc Fusion Protein, 0,1 mg

Details

Thrombopoietin (TPO), also known as Thrombopoiesis Stimulating Factor (TSF), is a glycoprotein hormone and the major stimulator of megakaryopoiesis and platelet production. TPO is expressed in liver, kidney, spleen, lung, bone marrow, and brain. The TPO receptor is a product of the proto-oncogene c-mpl and displays homology with type I cytokine receptor superfamily members. The receptor is present mainly on hematopoietic stem cells, megakaryocytic progenitors, megakaryocytes, and platelets. TPO is the primary regulator of platelet production by megakaryocytes. It stimulates the proliferation of hematopoietic stem cells, primitive progenitors, megakaryocytes, and platelets. Analogous to the effect of erythropoietin (EPO), the primary mode of action of TPO is inhibition of apoptosis of its target cells. By contrast, TPO is strongly proapoptotic in the brain and acts as a counterpart of EPO which has neuroprotective properties.Mouse TPO (Ser22-Thr356) is expressed recombinantly, purified by chromatography, sterile filtered and lyophilized. Mouse TPO can be used for a variety of applications, including megakaryocyte proliferation and differentiation in vitro, in vitro expansion of hematopoietic stem cells, in vitro platelet activation and apoptosis assays. >95percent pure by SDS-PAGE and biologically active as measured in a proliferation assay with human TF-1 erythroleukemia cells (Drexler et al. (1997) Leukemia 11:541-551).

Zusatzinformation

Artikelnummer MOIMTPO-FC-0,1
Hersteller Molecular Innovations
Herstellernummer MTPO-FC-0,1
Verpackungseinheit 0,1 mg
Mengeneinheit FL
Reaktivität Mouse (Murine)
Klonalität Keine Herstellerangabe
Wirt / Host Keine Herstellerangabe
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Auf Anfrage
MSDS Download