• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Recombinant Human AT-rich interactive domain-containing protein 1A(ARID1A),partial

Recombinant Human AT-rich interactive domain-containing protein 1A(ARID1A),partial
254,00 €
Artikelnummer: CSB-BP002058HU1-10

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human AT-rich interactive domain-containing protein 1A(ARID1A),partial, Host: Baculovirus

Details

Organism: Homo sapiens (Human). Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Involvement in disease: Coffin-Siris syndrome 2 (CSS2). Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Zusatzinformation

Artikelnummer CSB-BP002058HU1-10
Hersteller Cusabio
Herstellernummer CSB-BP002058HU1-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage