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Recombinant Human Cartilage intermediate layer protein 1(CILP),partial

Recombinant Human Cartilage intermediate layer protein 1(CILP),partial
1.056,00 €
Artikelnummer: CSB-BP005437HU-100

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human Cartilage intermediate layer protein 1(CILP),partial, Host: Baculovirus

Details

Organism: Homo sapiens (Human). Function: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Involvement in disease: Intervertebral disc disease (IDD). Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged

Zusatzinformation

Artikelnummer CSB-BP005437HU-100
Hersteller Cusabio
Herstellernummer CSB-BP005437HU-100
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage