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Recombinant Human Cyclin-dependent kinase4(CDK4)

Recombinant Human Cyclin-dependent kinase4(CDK4)
1.143,00 €
Artikelnummer: CSB-BP005065HU-500

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human Cyclin-dependent kinase4(CDK4), Host: Baculovirus

Details

Organism: Homo sapiens (Human). Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Involvement in disease: Melanoma, cutaneous malignant 3 (CMM3). Subcellular Location: Cytoplasm, Nucleus, Membrane. Protein Families: Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. Tag Info: N-terminal 6xHis-tagged

Zusatzinformation

Artikelnummer CSB-BP005065HU-500
Hersteller Cusabio
Herstellernummer CSB-BP005065HU-500
Verpackungseinheit 500 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage