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Recombinant Human Epidermal growth factor receptor(EGFR),partial

Recombinant Human Epidermal growth factor receptor(EGFR),partial
190,00 €
Artikelnummer: CSB-MP007479HU-10

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human Epidermal growth factor receptor(EGFR),partial, Host: Mammalian cell

Details

Organism: Homo sapiens (Human). Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity). Involvement in disease: Lung cancer (LNCR); Inflammatory skin and bowel disease, neonatal, 2 (NISBD2). Subcellular Location: Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Endosome, Endosome membrane, Nucleus. Protein Families: Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily. Tissue Specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Zusatzinformation

Artikelnummer CSB-MP007479HU-10
Hersteller Cusabio
Herstellernummer CSB-MP007479HU-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Mammalian Cell
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage