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Recombinant Human immunodeficiency virus type 1 group M subtype B Virion infectivity factor(vif)

Recombinant Human immunodeficiency virus type 1 group M subtype B Virion infectivity factor(vif)
970,00 €
Artikelnummer: CSB-YP303185HKM-200

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human immunodeficiency virus type 1 group M subtype B Virion infectivity factor(vif), Host: Yeast

Details

Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1). Function: Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells. Subcellular Location: Host cytoplasm, Host cell membrane, Peripheral membrane protein, Cytoplasmic side, Virion. Protein Families: Primate lentivirus group Vif protein family. Tag Info: N-terminal 6xHis-sumostar-tagged

Zusatzinformation

Artikelnummer CSB-YP303185HKM-200
Hersteller Cusabio
Herstellernummer CSB-YP303185HKM-200
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Yeast
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage