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Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial

Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial
212,00 €
Artikelnummer: CSB-MP011087HU-10

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial, Host: Mammalian cell


Organism: Homo sapiens (Human). Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways. Involvement in disease: Insulin-like growth factor 1 resistance (IGF1RES). Subcellular Location: Cell membrane, Single-pass type I membrane protein. Protein Families: Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily. Tissue Specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. Tag Info: N-terminal 10xHis-tagged


Artikelnummer CSB-MP011087HU-10
Hersteller Cusabio
Herstellernummer CSB-MP011087HU-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Mammalian Cell
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage