• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Recombinant Human Interferon regulatory factor 7(IRF7)

Recombinant Human Interferon regulatory factor 7(IRF7)
365,00 €
Artikelnummer: CSB-EP011822HU-50

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human Interferon regulatory factor 7(IRF7), Host: E.coli

Details

Organism: Homo sapiens (Human). Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. Involvement in disease: Immunodeficiency 39 (IMD39). Subcellular Location: Nucleus, Cytoplasm. Protein Families: IRF family. Tissue Specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes. Tag Info: Tag-Free

Zusatzinformation

Artikelnummer CSB-EP011822HU-50
Hersteller Cusabio
Herstellernummer CSB-EP011822HU-50
Verpackungseinheit 50 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Escherichia Coli
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage