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Recombinant Human parvovirus B19 Capsid protein VP1,partial

Recombinant Human parvovirus B19 Capsid protein VP1,partial
271,00 €
Artikelnummer: CSB-BP362102HPM-20

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human parvovirus B19 Capsid protein VP1,partial, Host: Baculovirus

Details

Organism: Homo sapiens (Human) parvovirus B19 (isolate AU) . Function: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity). Subcellular Location: Virion, Host nucleus. Protein Families: Parvoviridae capsid protein family. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Zusatzinformation

Artikelnummer CSB-BP362102HPM-20
Hersteller Cusabio
Herstellernummer CSB-BP362102HPM-20
Verpackungseinheit 20 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage