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Recombinant Human Protein cereblon(CRBN)

Recombinant Human Protein cereblon(CRBN)
1.889,00 €
Artikelnummer: CSB-BP842761HU-1

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human Protein cereblon(CRBN), Host: Baculovirus

Details

Organism: Homo sapiens (Human). Function: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. Involvement in disease: Mental retardation, autosomal recessive 2A (MRT2A). Subcellular Location: Cytoplasm, Nucleus, Membrane, Peripheral membrane protein. Protein Families: CRBN family. Tissue Specificity: Widely expressed. Highly expressed in brain. Tag Info: C-terminal 9xHis-tagged

Zusatzinformation

Artikelnummer CSB-BP842761HU-1
Hersteller Cusabio
Herstellernummer CSB-BP842761HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage