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Recombinant Human Protein disulfide-isomerase(P4HB),partial

Recombinant Human Protein disulfide-isomerase(P4HB),partial
1.472,00 €
Artikelnummer: CSB-YP017342HUF8-1

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human Protein disulfide-isomerase(P4HB),partial


Organism: Homo sapiens (Human). Function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Involvement in disease: Cole-Carpenter syndrome 1 (CLCRP1). Subcellular Location: Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Cell membrane, Peripheral membrane protein. Protein Families: Protein disulfide isomerase family. Tag Info: N-terminal 6xHis-tagged and C-terminal 10xHis-tagged


Artikelnummer CSB-YP017342HUF8-1
Hersteller Cusabio
Herstellernummer CSB-YP017342HUF8-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Yeast
Methode Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
Isotype Keine Herstellerangabe
Gene ID Keine Herstellerangabe
Datenblatt Auf Anfrage
MSDS Auf Anfrage