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Recombinant Human R-spondin-1(RSPO1),partial

Recombinant Human R-spondin-1(RSPO1),partial
106,00 €
Artikelnummer: CSB-AP005721HU-10

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Human R-spondin-1(RSPO1),partial, Host: Mammalian cell

Details

Species: Homo sapiens (Human). Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1. Involvement in disease: Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC). Subcellular Location: Secreted, Nucleus. Protein Families: R-spondin family. Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. Tag Info: C-terminal 6xHis-tagged.

Zusatzinformation

Artikelnummer CSB-AP005721HU-10
Hersteller Cusabio
Herstellernummer CSB-AP005721HU-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Mammalian Cell
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage