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Recombinant Human Receptor-interacting serine/threonine-protein kinase 1(RIPK1),partial

Recombinant Human Receptor-interacting serine/threonine-protein kinase 1(RIPK1),partial
755,00 €
Artikelnummer: CSB-BP618785HU2-50

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human Receptor-interacting serine/threonine-protein kinase 1(RIPK1),partial, Host: Baculovirus

Details

Organism: Homo sapiens (Human). Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. Subcellular Location: Cytoplasm, Cell membrane. Protein Families: Protein kinase superfamily, TKL Ser/Thr protein kinase family. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Zusatzinformation

Artikelnummer CSB-BP618785HU2-50
Hersteller Cusabio
Herstellernummer CSB-BP618785HU2-50
Verpackungseinheit 50 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Various hosts
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage