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Recombinant Human RNA-binding motif protein, X chromosome(RBMX),partial

Recombinant Human RNA-binding motif protein, X chromosome(RBMX),partial
421,00 €
Artikelnummer: CSB-EP019444HU1-100

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human RNA-binding motif protein, X chromosome(RBMX),partial, Host: E.coli

Details

Tag Info: N-terminal GST-tagged. MW: 33.4 kDa. Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. Involvement in disease: Mental retardation, X-linked, syndromic, 11 (MRXS11) . Subcellular Location: Nucleus. Tissue Specificity: Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).

Zusatzinformation

Artikelnummer CSB-EP019444HU1-100
Hersteller Cusabio
Herstellernummer CSB-EP019444HU1-100
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Escherichia Coli
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage