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Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1(SMARCB1),partial

Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1(SMARCB1),partial
125,00 €
Artikelnummer: CSB-EP623654HUA0-10

Verfügbarkeit: Lieferzeit auf Anfrage

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Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1(SMARCB1),partial, Host: E.coli

Details

Organism: Homo sapiens (Human). Function: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Involvement in disease: Rhabdoid tumor predisposition syndrome 1 (RTPS1); Schwannomatosis 1 (SWNTS1); Coffin-Siris syndrome 3 (CSS3). Subcellular Location: Nucleus. Protein Families: SNF5 family. Tag Info: N-terminal 6xHis-tagged

Zusatzinformation

Artikelnummer CSB-EP623654HUA0-10
Hersteller Cusabio
Herstellernummer CSB-EP623654HUA0-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Keine Herstellerangabe
Wirt / Host Escherichia Coli
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage