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Recombinant Mouse Ephrin-A1(Efna1),partial

Recombinant Mouse Ephrin-A1(Efna1),partial
70,00 €
Artikelnummer: CSB-AP005771MO-50

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs ab EUR 100,-
Recombinant Mouse Ephrin-A1(Efna1),partial, Host: Mammalian cell

Details

Species: Mus musculus (Mouse). Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Subcellular Location: Cell membrane, Lipid-anchor, GPI-anchor, SUBCELLULAR LOCATION: Ephrin-A1, secreted form: Secreted. Protein Families: Ephrin family. Tissue Specificity: Expressed in myogenic progenitor cells. Tag Info: C-terminal 6xHis-FC-tagged.

Zusatzinformation

Artikelnummer CSB-AP005771MO-50
Hersteller Cusabio
Herstellernummer CSB-AP005771MO-50
Verpackungseinheit 50 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Mammalian Cell
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage