Recombinant Mouse fMet-Leu-Phe receptor(Fpr1),partial

Tag Info: N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged. MW: 33.7 kDa. Function: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane, Multi-pass membrane protein. Protein Families: G-protein coupled receptor 1 family. Tissue Specificity: Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.