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Recombinant Mouse Interferon regulatory factor 3(Irf3)

Recombinant Mouse Interferon regulatory factor 3(Irf3)
350,00 €
Artikelnummer: CSB-EP011818MO-100

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Mouse Interferon regulatory factor 3(Irf3), Host: E.coli

Details

Organism: Mus musculus (Mouse). Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. Subcellular Location: Cytoplasm, Nucleus. Protein Families: IRF family. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Zusatzinformation

Artikelnummer CSB-EP011818MO-100
Hersteller Cusabio
Herstellernummer CSB-EP011818MO-100
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Escherichia Coli
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage