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Recombinant Rat Transforming growth factor beta-1(Tgfb1),partial

Recombinant Rat Transforming growth factor beta-1(Tgfb1),partial
680,00 €
Artikelnummer: CSB-EP023446RAA0-200

Verfügbarkeit: Lieferzeit auf Anfrage

Kostenlose Lieferung innerhalb Österreichs!
Recombinant Rat Transforming growth factor beta-1(Tgfb1),partial, Host: E.coli

Details

Tag Info: N-terminal 6xHis-tagged. MW: 34.0 kDa. Function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity). Subcellular Location: Secreted, extracellular space, extracellular matrix. Protein Families: TGF-beta family. Tissue Specificity: Abundant in the bone matrix.

Zusatzinformation

Artikelnummer CSB-EP023446RAA0-200
Hersteller Cusabio
Herstellernummer CSB-EP023446RAA0-200
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Keine Herstellerangabe
Klonalität Keine Herstellerangabe
Wirt / Host Escherichia Coli
Methode Keine Herstellerangabe
Isotype Keine Herstellerangabe
Gene ID Nein
Datenblatt Auf Anfrage
MSDS Auf Anfrage