Product Type: Inhibitor
CAS No.: 467214-20-6
MolecularFormula: C32H48N4O8
Molecular Weight: 616,8
Source: Synthetic
Purity: >98% (TLC); NMR conforms
Solubility: Soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml)
Appearance: Purple Solid
PubChem CID: 5288674
Scientific Background: 17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG. It clears alpha-synuclein aggregates by inducton of autophagy (4).
References: 1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077.2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813. 4. RA Frake et al. (2015) J Clin Invest. 125(1): 65-74.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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