α-Cyano-4-hydroxycinnamic acid, CAS 28166-41-8

Product Description: α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C10H7NO3

References: [1]A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96./[2]Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56./[3]Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405(12):4289-93.

CAS Number: 28166-41-8

Molecular Weight: 189.17

Compound Purity: 99.98

Research Area: Metabolic Disease

Solubility: DMSO : 250 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Monocarboxylate Transporter

• Artikelnummer: MEXHY-107641-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107641-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK