Target Synonym: IMD;IDDM;IL2RA;CD25;IDDM10;IL2R;IMD41;TCGFR;p55;IL-2 receptor subunit alpha;IL-2R subunit alpha;IL2-RA;IL-2-RA;IL-2Rα;Interleukin-2 receptor subunit alpha;TAC antigen;Tac;p55;IL-2Rαalpha chain;CD25 antigen;IL 2 receptor alpha subunit;IL2 RA;Interleukin 2 receptor;Interleukin 2 receptor alpha;Interleukin 2 receptor alpha chain;t-cell growth factor receptor
Background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Immunogen: Recombinant Human CD25 protein
Buffer: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Dilution: FCM 2 μg/mL(1×105-5×105 cells)