Target: Amyloid Oligomers (A11)
Conjugate: ATTO 390
Product Type: Polyclonal
Immunogen: Synthetic molecular mimic of soluble human amyloid beta oligomers
Swiss-Prot: P05067
Purification: Protein A Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Specificity: Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Cellular Localization: Membrane
Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
References: 1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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