Anti-HNF-4-alpha Antibody Picoband™ (monoclonal, 6C8E9)

Clone Number: 6C8E9

Immunogen: E.coli-derived human HNF-4-alpha recombinant protein (Position: Q164-I474). Human HNF-4-alpha shares 95% and 96% amino acid (aa) sequence identity with mouse and rat HNF-4-alpha, respectively.

Concentration: Adding 0.2 ml of distilled water =f 500 μg/ml.

Format: Lyophilized

Storage buffer: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Additional info: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. Background: Hepatocyte nuclear factor 4 alpha (HNF4A), also known as NR2A1, is a nuclear receptor that in humans is encoded by the HNF4A gene. It is mapped to 20q13.12. HNF4A is a nuclear transcription factor that binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene plays a role in development of the liver, kidney, and intestines. HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4. This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Oestrogen as-well as prolonging the half-life of Testosterone. Subcellular Localization: Tissue Specificity:

• Artikelnummer: SANMON23868
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23868
• Green Labware: Nein
• Verpackungseinheit: 100μg
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG2a
• Wirt: Mouse