Aphidicolin, CAS 38966-21-1

DNA polymerase inhibitor

Product Type: Inhibitor.

CAS No.: 38966-21-1.

MolecularFormula: C20H34O4.

Molecular Weight: 338,5.

Source: Synthetic.

Purity: >98% (TLC); NMR (Conforms).

Solubility: May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml).

Appearance: White powder.

PubChem CID: 457964.

Scientific Background: Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4).

References: 1. Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668. 2. Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168. 3. Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916. 4. Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-605-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-605-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK