Product Description: Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C9H16ClN3O
References: [1]Altamirano-Espinoza AH, et al. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38. /[2]Capey S. Azepexole[J]. 2007.Pharm: The Comprehensive Pharmacology Reference.
CAS Number: 147663-20-5
Molecular Weight: 217.70
Compound Purity: 95.35
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Adrenergic Receptor
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