Beclin 1 Antibody: ATTO 390

Rabbit Anti-Human Beclin 1 Polyclonal
Artikelnummer
STRSPC-601D-A390
Verpackungseinheit
100 µg
Hersteller
Stressmarq Biosciences

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Target: Beclin 1

Conjugate: ATTO 390

Product Type: Polyclonal

Immunogen: Synthetic peptide from the C-terminus of human Beclin 1

Swiss-Prot: Q14457

Purification: Peptide Affinity Purified

Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Concentration: 1 mg/ml

Specificity: Predicted molecular weight at ~51kDa.

Cellular Localization: Cytoplasm / Golgi apparatus / Trans-Golgi network membrane/ Endosome / Endoplasmic reticulum membrane / Mitochondrion / Mitochondrion membrane / Cytoplasmic vesicle / Autophagosome

Scientific Background: Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an inportant role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent train of Sindbis virus (4).

References: 1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476.2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449.3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132.4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Mehr Informationen
Artikelnummer STRSPC-601D-A390
Hersteller Stressmarq Biosciences
Hersteller Artikelnummer SPC-601D-A390
Verpackungseinheit 100 µg
Mengeneinheit STK
Reaktivität Human, Rat (Rattus)
Klonalität Polyclonal
Methode Immunofluorescence, Immunohistochemistry, Immunocytochemistry
Human Gene ID 8678
Wirt Rabbit
Konjugat Conjugated, Atto 390
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