Shelf life (days): 1460
Info: An isoquinoline alkaloid with diverse biological activities; active metabolite of berberine; scavenges hydroxyl radicals and chelates ferrous iron in cell-free assays at 600 µM; potentiates topoisomerase II-induced cleavage of isolated E. coli DNA at 10 µM; inhibits MPP+ uptake in MDCK cells expressing human OCT1, OCT2, or OCT3 (IC50s = 1.26, 8.3, and 4.88 µM, respectively); decreases triglyceride levels without inducing cytotoxicity in HepG2 cells at 15 µM; increases intestinal length, decreases disease severity and colonic epithelial deterioration, reduces colonic TNF-α, IFN-γ, IL-6, IL-1β, IL-4, and IL-10 levels, and decreases colonic MPO activity in a mouse model of DSS-induced ulcerative colitis at 20 mg/kg per day
Formulation: A solid
Formal Name: 5,6-dihydro-9-hydroxy-10-methoxy-bnzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride
Purity: ≥98%
Formula Markup: C19H16NO4 • Cl
Formula Weight: 357.78738
CAS Number: 15401-69-1
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