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Biotinylated CCL19 Protein
Biotinylated CCL19 Protein
Artikelnummer
AVIOPCB00021-5UG
Verpackungseinheit
5µg
Hersteller
Aviva Systems Biology
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Conjugation: Biotin
Description of Target: Macrophage inflammatory protein-3-beta (MIP3-beta) (CCL19), also known as EBI1 ligand chemokine (ELC), directs chemotaxis of dendritic cells, and certain B- and T- lymphocytes, but not monocytes or granulocytes. It is constituitively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. Being a homeostatic chemokine, its primary physiological role is considered to be in the normal recirculation and homing of lymphocyte. However, MIP3-beta could also be proinfammatory, and is implicated in the post-HIV infection responses.
Key Reference: 1. "Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7"
Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O.
J Biol Chem 272:13803-13809 (1997)
2. "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells."
Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E.
J. Immunol. 160:2418-2424(1998)
3. "Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication."
Damås J.K., Landrø L., Fevang B., Heggelund L., Tjønnfjord G.E., Fløisand Y., Halvorsen B., Frøland S.S., Aukrust P.
Clin Exp Immunol. 157:400-7 (2009)
Molecular Weight: 11 kDa
Product Format: Lyophilized.
Purity: > 97% as determined by SDS-PAGE
Source: E. coli
Description of Target: Macrophage inflammatory protein-3-beta (MIP3-beta) (CCL19), also known as EBI1 ligand chemokine (ELC), directs chemotaxis of dendritic cells, and certain B- and T- lymphocytes, but not monocytes or granulocytes. It is constituitively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. Being a homeostatic chemokine, its primary physiological role is considered to be in the normal recirculation and homing of lymphocyte. However, MIP3-beta could also be proinfammatory, and is implicated in the post-HIV infection responses.
Key Reference: 1. "Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7"
Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O.
J Biol Chem 272:13803-13809 (1997)
2. "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells."
Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E.
J. Immunol. 160:2418-2424(1998)
3. "Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication."
Damås J.K., Landrø L., Fevang B., Heggelund L., Tjønnfjord G.E., Fløisand Y., Halvorsen B., Frøland S.S., Aukrust P.
Clin Exp Immunol. 157:400-7 (2009)
Molecular Weight: 11 kDa
Product Format: Lyophilized.
Purity: > 97% as determined by SDS-PAGE
Source: E. coli
| Artikelnummer | AVIOPCB00021-5UG |
|---|---|
| Hersteller | Aviva Systems Biology |
| Hersteller Artikelnummer | OPCB00021-5UG |
| Green Labware | Nein |
| Verpackungseinheit | 5µg |
| Mengeneinheit | STK |
| Methode | Cell Assay |
| Human Gene ID | 6363 |
| Produktinformation (PDF) |
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| MSDS (PDF) |
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Gernot Ensinger, M.Sc.
