Shelf life (days): 1460
Info: An Itk inhibitor (IC50 = 19 nM); selective for Itk over 18 other kinases (IC50s = >1,100 nM for all); inhibits IL-2 secretion from Jurkat T cells and isolated human PBMCs induced by antibodies targeting CD3 (IC50s = 0.25 and 0.39 µM, respectively); decreases serum levels of Il-2 and the lung infiltration of total immune cells and eosinophils in a mouse model of ovalbumin-induced lung inflammation at 25 mg/kg; reduces ear skin thickness and decreases the number of infiltrating immune cells in a mouse model of imiquimod-induced skin inflammation when topically applied at 3%
Formulation: A solid
Formal Name: N-[5-[[5-[(4-acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]-benzamide
Purity: ≥95%
Formula Markup: C32H41N5O4S2
Formula Weight: 623.83124
CAS Number: 439575-02-7
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